From 23 December 2024 - 03 January 2025 the ISRCTN team will be working at a reduced capacity. It may take longer than usual to process your applications and requests during this period. The ISRCTN office is closed on 25 & 26 December 2024 and 01 January 2025 for public holidays in the UK.
The ISRCTN registry is a primary clinical study registry recognised by the World Health Organisation (WHO) and the International Committee of Medical Journal Editors (ICMJE) that accepts all clinical research studies (whether proposed, ongoing or completed), providing content validation and curation and the unique identification number necessary for publication. All study records in the database are freely accessible and searchable.
ISRCTN supports transparency in clinical research, helps reduce selective reporting of results and ensures an unbiased and complete evidence base.
The registry aims to include all interventional and non-interventional clinical studies that prospectively involve UK participants and evaluate biomedical or health-related outcomes.
Studies conducted outside the UK or considered to be non-clinical studies (e.g. public health studies) can be registered on ISRCTN.
Studies should ideally be registered prospectively (before recruitment starts). ISRCTN also accepts studies registered retrospectively once they are underway or after completion.
Comparative effectiveness of injecting botulinum toxin type A in the masseter muscle only to the additional injection in the lateral pterygoid muscle in patients with bruxism: a randomized controlled trial
A randomized controlled trial assessing the effect of preoperative ibuprofen administration on postoperative pain reduction following mini-screw insertion for patients with malocclusion
A single ascending dose trial investigating the safety and feasibility of autologous thymus derived regulatory T cell (Tregs) treatment for the prevention of cardiac allograft vasculopathy in children receiving heart transplant
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